GMAT Reading Comprehension Discussions


The passage suggests that which of the following
lines of inquiry would be most useful in determining
the relevance of the research done on Tay-Sachs
disease to lysosomal storage diseases generally? But don’t have OA …

  • How many different mutations are present in the defective genes responsible for other lysosomal storage diseases?
  • What purpose does GM2 ganglioside serve in the human body?
  • Does the onset of other lysosomal storage diseases vary with the location of mutations in DNA sequences?
  • Do other lysosomal storage diseases affect the hexosaminidase gene?
  • Do patients suffering from other lysosomal storage diseases have the same mortality rate as those suffering from Tay-Sachs?

0 voters

Lysosomal storage diseases form a category of genetic disorders resulting from defective enzymes that normally function to degrade unneeded molecules in cells. These enzymes do their work in the lysosome, a small compartment in a cell analogous to a garbage disposal. The lysosome contains between thirty and forty different degradative enzymes. When any one of the lysosomal enzymes is defective, the molecules requiring that specific enzyme for their degradation will accumulate and cause that individual's lysosomes to swell enormously. The physiological effects of such swelling on the individual include motor and mental deterioration, often to the point of premature death. But each disease resulting from one specific defective lysosomal enzyme has its own characteristic pathology. The age of onset, rate of progression, and severity of the clinical symptoms observed in patients with the same defective lysosomal enzyme are highly variable. For many years, this variability in patients with the same defective enzyme puzzled scientists. Only recently have researchers begun to answer the riddle, thanks to a genetic analysis of a lysosomal storage disorder known as Tay-Sachs disease. As in most lysosomal storage diseases, patients suffering from Tay-Sachs disease show both mental and motor deterioration and variability in age of onset, progression, and severity. Physicians have categorized the patients into three groups: infantile, juvenile, and adult, based on onset of the disease. The infantile group begins to show neurodegeneration as early as six months of age. The disease advances rapidly and children rarely live beyond 3 years old. The first symptoms of the disease appear in juvenile cases between 2 and 5 years of age, with death usually occurring around age 15. Those with the adult form generally live out a normal lifespan, suffering from milder symptoms than do those with the infantile and juvenile forms. Researchers hoped that the categorization would yield insight into the cause of the variability of symptoms among Tay-Sachs patients, but this turned out not to be the case. In Tay-Sachs disease, undegraded materials accumulate mainly in the lysosomes in the brains of patients, but the kinds of molecules left undegraded and the specific identity of the defective lysosomal enzyme responsible for the malfunction were not discovered until the 1950s and 60s, respectively. The main storage molecule was found to be a lipid-like material known as GM2 ganglioside. The defective enzyme was later identified as hexosaminidase. In 1985, the gene coding for the normal hexosaminidase enzyme was cloned and its DNA sequence determined. Shortly thereafter, the DNA sequences of genes encoding hexosaminidase from many Tay-Sachs patients were studied. It soon became apparent that not one or two but many different types of mutations in the hexosaminidase gene could result in Tay-Sachs disease. Some of the mutations prevented the synthesis of any hexosaminidase, preventing all such enzyme activity in the cell. Patients with this type of mutation all had the infantile form of Tay-Sachs disease. Other mutations were found in certain regions of the gene coding for areas of the enzyme known to be critical for its catalytic activity. Such mutations would allow for only extremely crippled hexosaminidase activity. Most of the patients with these mutations clustered in the juvenile category. Adult Tay-Sachs patients presented mutations in the regions of the hexosaminidase gene that were less important for the enzyme's activity than were those affected in juvenile patients. Scientists quickly hypothesized that the variation in age of onset and severity of Tay-Sachs disease correlated with the amount of residual enzymatic activity allowed by the genetic mutation. Though more research is needed to demonstrate similarity with other lysosomal storage diseases, the work done on Tay-Sachs disease has already offered a promising glimpse into the underlying mechanisms of these disorders.


It can be inferred from the passage that which of the following statements is true of lysosomal storage diseases? 

  • They are generally caused by mutations to the hexosaminidase gene.
  • Their causes were unknown before the 1950s.
  • They are most lethal when onset is in a patient’s infancy.
  • They can be fatal even when allowing some enzymatic activity.
  • They are undetectable until physical symptoms are present

0 voters


5. The author mentions “pigs and chickens” in the final paragraph in order to   

  • < provide specific examples of other animals whose dendritic cells are exploited by Toxoplasma
  • < provide specific examples of animals that are often eaten by cats
  • < provide specific examples of animals that can carry Toxoplasma
  • < provide specific examples of animals that are immune to Toxoplasma
  • < provide specific examples of animals in which Toxoplasma can breed

0 voters


4. Which of the following is the most likely outcome for
Toxoplasma cells that invade the human body?    

  • < They will be destroyed by the immune system.
  • < They will collect in the lymphatic system.
  • < They will not reproduce.
  • < They will be detected after several weeks.
  • < They will be destroyed by other pathogens in the bloodstream.

0 voters


3. The second paragraph performs which of the
following functions in the passage?  

  • < It discusses an outdated scientific model that has been discredited and offers a new model in its place.
  • < It introduces information that is essential to understanding the role of Toxoplasma in human development.
  • < It describes the mechanism by which Toxoplasma is able to parasitize the human body.
  • < It presents a recommendation based on the new understanding of Toxoplasma.
  • < It summarizes the research that remains to be done regarding Toxoplasma.

0 voters


2. According to the passage, all of the following are
true of Toxoplasma gondii EXCEPT 

  • < it can alter the usual behavior of human cells
  • < it enters the human body through the food chain
  • < it can contaminate ground water
  • < it must find a host cat in order to reproduce
  • < the human body is incapable of detecting it

0 voters


1. It can be inferred from the passage that which of the
following statements is true of dendritic cells in the
human body?   

  • < Most dendritic cells of persons infected with Toxoplasma carry the parasite.
  • < They are produced by the lymphatic system.
  • < They are able to penetrate the membranes surrounding the brain.
  • < They are the only cells capable of being infected by Toxoplasma.
  • < They are more numerous in the digestive tract than in any other part of the human body.

0 voters


The single-celled parasite known as Toxoplasma gondii infects more than half of the world's human population without creating any noticeable symptoms. Once inside the human body, Toxoplasma rapidly spreads to the heart and other organs. It can even penetrate the tight barrier that normally protects the brain from most pathogens. Yet, the blood of infected persons carries very few freefloating Toxoplasma cells. Scientists have long been puzzled by this ability of Toxoplasma to parasitize the human body without triggering an immune response and without an appreciable presence in the bloodstream. Recent research, however, has shed light on the ways in which Toxoplasma achieves its remarkable infiltration of the human body.

Though there are few individual Toxoplasma cells coursing freely in the blood of an infected person, scientists have discovered that the parasite is quite common in certain cells, known as dendritic cells, involved in the human immune system. Dendritic cells are found in the digestive tract and frequently come into contact with the various pathogens that enter the human body through food and water. When the dendritic cells encounter pathogens, they travel to lymph nodes and relay this information to other immune cells that then take action against the reported pathogen. Scientists have found, however, that Toxoplasma is capable of hijacking dendritic cells, forcing them from their usual activity and using them as a form of transportation to infect the human body quickly. Without this transport mechanism, Toxoplasma could not reach the better-protected areas of the body.

Toxoplasma invades the human body through consumption of the undercooked meat of infected animals, primarily pigs and chickens. Other animals, such as cats, can become infected as well. In fact, cats are a necessary component in the reproductive cycle of Toxoplasma, since the animal's intestines are the parasite's sole breeding ground. Toxoplasma creates egg-like cysts, known as oocysts, in the cats' intestines. These oocysts are shed in the cats' droppings and contaminate ground water and soil, eventually finding their way into the food chain. Because Toxoplasma must somehow find its way into a new host cat in order to reproduce, it cannot kill its current host. Instead, it waits for the host, usually a small rodent, to be eaten by a cat, thus providing Toxoplasma the opportunity to reproduce.

1. Based on information in the passage, with which of the following statements about opinions would the author most likely NOT disagree?



A. Different opinions exist because people are imperfect.


B. An opinion can be relatively harmless in one context and dangerous in another.


C. Opinions directed specifically against fellow human beings should be punished.


D. All expressions of opinion should really be considered actions.


E. An opinion always has an additional unintended effect


2. The author holds that one should not necessarily defer to the traditions and customs of other people. The author supports his position by arguing that:

I. traditions and customs are usually the result of misinterpreted experiences.

II. customs are based on experiences in the past, which are different from modern experiences.

III. customs can stifle one's individual development.

A. II only

B. III only

C. I and III only

D. II and III only

E. None




3. The existence of which of the following phenomena would most strongly challenge the author's argument about ―"conforming to custom merely as custom"?


A. A class in morality taught at a parochial high school

B. An important discovery made by a researcher who uses unconventional methods

C. A culture in which it is traditional to let children make their own decisions

D. A custom that involves celebrating a noteworthy historical event

E. a culture in which only the senior most person takes the important decisions


Those who opine lose their impunity when the circumstances in which they pontificate are such that generate from their expression a positive instigation of some mischievous act. An opinion that corn dealers are starvers of the poor, or that owning private property is robbery, ought to be unmolested when simply circulated through the press, but may justly incur punishment when delivered orally to an excited mob assembled before the house of a corn dealer, or when handed about among the same mob in the form of a placard. Acts, of whatever kind, which without justifiable cause do harm to others, may be, and in the more important cases are absolutely required to be, controlled by the unfavourable sentiments, and, when needful, by the active interference of mankind. The liberty of the individual must be thus far limited; he must not make himself a nuisance to other people. But if he refrains from molesting others in matters that concern them, and merely acts according to his own inclination and judgment in matters which concern himself he should be allowed, without molestation, to carry his opinions into practice at his own cost. As it is useful that while mankind are imperfect there should be different opinions, so it is that there should be different experiments of living, that free scope should be given to varieties of character, short of injury to others, and that the worth of different modes of life should be proved practically, when anyone thinks fit to try them. Where not the person's own character but the traditions and customs of other people are the rule of conduct, there is wanting one of the principal ingredients of individual and social progress.

It would be absurd to pretend that people ought to live as if nothing whatever had been known in the world before they came into it; as if experience had as yet done nothing toward showing that one mode of existence, or of conduct, is preferable to another. Nobody denies that people should be so taught and trained in youth as to know and benefit by the ascertained results of human experience. But it is the privilege and proper condition of a human being, arrived at the maturity of his faculties, to use and interpret experience in his own way. It is for him to find out what part of recorded experience is properly applicable to his own circumstances and character. The traditions and customs of other people are, to a certain extent, evidence of what their experience has taught them-presumptive evidence, and as such, have a claim to his deference-but, in the first place, their experience may be too narrow, or they may have not interpreted it rightly. Secondly, their interpretation of experience may be correct, but unsuited to him. Customs are made for customary circumstances and customary characters, and his circumstances or his character may be uncustomary. Thirdly, though the customs be both good as customs and suitable to him, yet to conform to custom merely as custom does not educate him or develop in him any of the qualities which are the distinctive endowments of a human being. He gains no practice either in discerning or desiring what is best.

Puys.. I find the Philosophical RCs very tough.... I take much time in reading them and still commit mistake in the followup questions.... how to overcome this weakness??

Planter-legislators of the post-Civil War southern United States enacted crop lien laws stipulating that those who advanced cash or supplies necessary to plant a crop would receive, as security, a claim, or lien, on the crop produced. In doing so, planters, most of whom were former slaveholders, sought access to credit from merchants and control over nominally free laborers--former slaves freed by the victory of the northern Union over the southern Confederacy in the United States Civil War. They hoped to reassure merchants that despite the emancipation of the slaves, planters would produce crops and pay debts. Planters planned to use their supply credit to control their workers, former slaves who were without money to rent land or buy supplies. Planters imagined continuation of the pre-Civil War economic hierarchy: merchants supplying landlords, landlords supplying laborers, and laborers producing crops from which their scant wages and planters' profits would come, allowing planters to repay advances. Lien laws frequently had unintended consequences, however, thwarting the planter fantasy of mastery without slavery. The newly freed workers, seeking to become self-employed tenant farmers rather than wage laborers, made direct arrangements with merchants for supplies. Lien laws, the centerpiece of a system designed to create a dependent labor force, became the means for workers, with alternative means of supply advances, to escape that dependence.


1. Which of the following best expresses the central idea of the passage?


A. Planters in the post-Civil War southern United States sought to reinstate the institution of slavery.


B. Through their decisions regarding supply credit, merchants controlled post-Civil War agriculture.


C. Lien laws helped to defeat the purpose for which they were originally created.


D. Although slavery had ended, the economic hierarchy changed little in the post-Civil War southern United States.


E. Newly freed workers enacted lien laws to hasten the downfall of the plantation economy.

2. According to the passage, each of the following was a reason planters supported crop lien laws EXCEPT:


A. Planters believed that lien laws would allow them to expand their landholdings.


B. Planters expected that lien laws would give them control over former slaves.


C. Planters anticipated that lien laws would help them retain access to merchant credit.


D. Planters intended to use lien laws to create a dependent labor force.


E. Planters saw lien laws as a way to maintain their traditional economic status.

3. The passage suggests which of the following about merchants in the post-Civil War southern United States?


A. They sought to preserve pre-Civil War social conditions.


B. Their numbers in the legislatures had been diminished.


C. Their businesses had suffered from a loss of collateral.


D. They were willing to make business arrangements with former slaves.


E. Their profits had declined because planters defaulted on debts for supply advances.

[Same Passage]


Which of the following best describes the structure of the first paragraph of the passage?

  • A historical era is described in terms of its political trends.
  • Two scholarly approaches are compared, and a shortcoming common to both is identifi ed.
  • Two rival schools of thought are contrasted, and a third is alluded to.
  • An outmoded scholarly approach is described, and a corrective approach is called for.
  • An argument is outlined, and counterarguments are mentioned.

0 voters

In a 1918 editorial, W.E.B. Du Bois advised African
Americans to stop agitating for equality and to
proclaim their solidarity with White Americans for
the duration of the First World War. The editorial
surprised many African Americans who viewed
Du Bois as an uncompromising African American
leader and a chief opponent of the accommodationist
tactics urged by Booker T.Washington. In fact,
however, Du Bois often shifted positions along the
continuum between Washington and
confrontationists such as William Trotter. In 1895,
when Washington called on African Americans to
concentrate on improving their communities instead
of opposing discrimination and agitating for political
rights, Du Bois praised Washington’s speech. In
1903, however, Du Bois aligned himself with Trotter,
Washington’s militant opponent, less for ideological
reasons than because Trotter had described to him
Washington’s efforts to silence those in the African
American press who opposed Washington’s
positions.


Du Bois’s wartime position thus reflected not a
change in his long-term goals but rather a
pragmatic response in the face of social pressure:
government officials had threatened African
American journalists with censorship if they
continued to voice grievances. Furthermore,
Du Bois believed that African Americans’
contributions to past war efforts had brought them
some legal and political advances. Du Bois’s
accommodationism did not last, however. Upon
learning of systematic discrimination experienced
by African Americans in the military, he called on
them to “return fighting” from the war.

The passage indicates which of the following about Du Bois’s attitude toward Washington ?

  • It remained consistently positive even though Du Bois disagreed with Washington’s efforts to control the African American press.
  • It underwent a shift in 1903 for reasons other than Du Bois’s disagreement with Washington’s accommodationist views.
  • It underwent a shift during the First World War as Du Bois became more sympathetic with Trotter’s views.
  • It was shaped primarily by Du Bois’s appreciation of Washington’s pragmatic approach to the advancement of the interests of African Americans.
  • It underwent a shift as Du Bois made a long-term commitment to the strategy of accommodation.

0 voters

[Need Help]

Findings from several studies on corporate mergers and acquisitions during the 1970s and 1980s raise questions about why firms initiate and consummate such transactions. One study showed, for example, that acquiring firms were on average unable to maintain acquired firms’ pre-merger levels of profitability. A second study concluded that postacquisition gains to most acquiring firms were not adequate to cover the premiums paid to obtain acquired firms. A third demonstrated that, following the announcement of a prospective merger, the stock of the prospective acquiring fi rm tends to increase in value much less than does that of the firm for which it bids. Yet mergers and acquisitions remain common, and bidders continue to assert that their objectives are economic ones.

Acquisitions may well have the desirable effect of channeling a nation’s resources efficiently from less to more efficient sectors of its economy, but the individual acquisitions executives arranging these deals must see them as advancing either their own or their companies’ private economic interests. It seems that factors having little to do with corporate economic interests explain acquisitions. These factors may include the incentive compensation of executives, lack of monitoring by boards of directors, and managerial error in estimating the value of firms targeted for acquisition. Alternatively, the acquisition acts of bidders may derive from
modeling: a manager does what other managers do.


The author of the passage mentions the effect of acquisitions on national economies most probably in order to

Hi Puys,

I am planning to write GMAT in a couple of months, mostly by August. When do you think would be the ideal time for me to give the exam keeping in mind that I would like to apply for SP Jain and ISB early entry program.

I have just graduated and will be working for Mu Sigma from July 16th. Have heard that the work there is quite strenuous and makes it tough for preparation and stuffs.

Though I have the OG as an e-book with me, I dont have any other preparation materials  and Mock exams with me. Kindly if possible send me links for E-books and mocks. Also I have listed my academic qualifications below, kindly look into it and assess if it is good enough for ISB and SP Jain?

Thanks 😃


10th-93.8%

12th-90.2%

B.Tech CGPA -9.46 

Not bad Extra curriculars.

Between the eighth and eleventh centuries A.D., the Byzantine Empire staged an almost unparalleled economic and cultural revival, a recovery that is all the more striking because it followed a long period of severe (5) internal decline. By the early eighth century, the empire had lost roughly two-thirds of the territory it had possessed in the year 600, and its remaining area was being raided by Arabs and Bulgarians, who at times threatened to take Constantinople and extinguish the (10) empire altogether. The wealth of the state and its subjects was greatly diminished, and artistic and literary production had virtually ceased. By the early eleventh century, however, the empire had regained almost half of its lost possessions, its new frontiers were secure, and its (15) influence extended far beyond its borders. The economy had recovered, the treasury was full, and art and scho- larship had advanced. To consider the Byzantine military, cultural, and economic advances as differentiated aspects of a single (20) phenomenon is reasonable. After all, these three forms of progress have gone together in a number of states and civilizations. Rome under Augustus and fifth-century Athens provide the most obvious examples in antiquity. Moreover, an examination of the apparent sequential (25) connections among military, economic, and cultural forms of progress might help explain the dynamics of historical change. The common explanation of these apparent conn- ections in the case of Byzantium would run like this: (30) when the empire had turned back enemy raids on its own territory and had begun to raid and conquer enemy territory, Byzantine resources naturally expanded and more money became available to patronize art and lit- erature. Therefore, Byzantine military achievements led to (35) economic advances, which in turn led to cultural revival. No doubt this hypothetical pattern did apply at times during the course of the recovery. Yet it is not clear that military advances invariably came first. economic advances second, and intellectual advances third. In the (40) 860‟s the Byzantine Empire began to recover from Arab incursions so that by 872 the military balance with the Abbasid Caliphate had been permanently altered in the empire‟s favor. The beginning of the empire‟s economic revival, however, can be placed between 810 and 830. (45) Finally, the Byzantine revival of learning appears to have begun even earlier. A number of notable scholars and writers appeared by 788 and, by the last decade of the eighth century, a cultural revival was in full bloom, a revival that lasted until the fall of Constantinople in (50) 1453.Thus the commonly expected order of military recovery was reversed in Byzantium. In fact, the revival of Byzantine learning may itself have influenced the subsequent economic and military expansion.


1. Which of the following best states the central idea of the passage?

(A) The Byzantine Empire was a unique case in which the usual order of military and economic revival preceding cultural revival was reversed.

(B) The economic, cultural, and military revival in the Byzantine Empire between the eighth and eleventh centuries was similar in its order to the sequence of revivals in Augustan Rome and fifth- century Athens.

(C) After 810 Byzantine economic recovery spurred a military and, later, cultural expansion that lasted until 1453.

(D) The eighth-century revival of Byzantine learning is an inexplicable phenomenon, and its economic and military precursors have yet to be discovered.

(E) The revival of the Byzantine Empire between the eighth and eleventh centuries shows cultural rebirth preceding economic and military revival, the reverse of the commonly accepted order of progress.

2. The primary purpose of the second paragraph is which of the following?

(A) To establish the uniqueness of the Byzantine revival

(B) To show that Augustan Rome and fifth-century Athens are examples of cultural, economic, and military expansion against which all subsequent cases must be measured

(C) To suggest that cultural, economic. and military advances have tended to be closely interrelated in different societies.

(D) To argue that, while the revivals of Augustan Rome and fifth-century Athens were similar, they are unrelated to other historical examples

(E) To indicate that, wherever possible, historians should seek to make comparisons with the earliest chronological examples of revival

3. It can be inferred from the passage that by the eleventh century the Byzantine military forces

(A) had reached their peak and begun to decline

(B) had eliminated the Bulgarian army

(C) were comparable in size to the army of Rome under Augustus

(D) were strong enough to withstand the Abbasid Caliphate‟s military forces

(E) had achieved control of Byzantine governmental structures

4. It can be inferred from the passage that the Byzantine Empire sustained significant territorial losses

(A) in 600

(B) during the seventh century

(C) a century after the cultural achievements of the Byzantine Empire had been lost

(D) soon after the revival of Byzantine learning

(E) in the century after 873 5.

5.In the third paragraph, the author most probably provides an explanation of the apparent connections among economic, military, and cultural development in order to

(A) suggest that the process of revival in Byzantium accords with this model

(B) set up an order of events that is then shown to be not generally applicable to the case of Byzantium

(C) cast aspersions on traditional historical scholarship about Byzantium

(D) suggest that Byzantium represents a case for which no historical precedent exists

(E) argue that military conquest is the paramount element in the growth of empires


6. Which of the following does the author mention as crucial evidence concerning the manner in which the Byzantine revival began?

(A) The Byzantine military revival of the 860‟s led to economic and cultural advances.

(B) The Byzantine cultural revival lasted until 1453.

(C) The Byzantine economic recovery began in the 900‟s.

(D) The revival of Byzantine learning began toward the end of the eighth century.

(E) By the early eleventh century the Byzantine Empire had regained much of its lost territory.

7. According to the author, "The common explanation" (line 28) of connections between economic, military, and cultural development is (A) revolutionary and too new to have been applied to the history of the Byzantine Empire

(B) reasonable, but an antiquated theory of the nature of progress

(C) not applicable to the Byzantine revival as a whole, but does perhaps accurately describe limited periods during the revival

(D) equally applicable to the Byzantine case as a whole and to the history of military, economic, and cultural advances in ancient Greece and Rome

(E) essentially not helpful, because military, economic, and cultural advances are part of a single phenomenon

Comment:

I am not understanding why my answer options are not correct in spite of having same sense as the answer choice. I need the cause for my wrong ans and also the correct ans for above questions. I have highlighted my ans choices with bold and also the questions


7. According to the author, "The common explanation" (line 28) of connections between economic, military, and cultural development is 

(B) 

(C) 

(D) 

(E) 

  • not applicable to the Byzantine revival as a whole, but does perhaps accurately describe limited periods during the revival
  • reasonable, but an antiquated theory of the nature of progress
  • revolutionary and too new to have been applied to the history of the Byzantine Empire
  • essentially not helpful, because military, economic, and cultural advances are part of a single phenomenon
  • equally applicable to the Byzantine case as a whole and to the history of military, economic, and cultural advances in ancient Greece and Rome

0 voters